CSF3R mutation analysis

Alphabetical Test listing

CSF3R mutation analysis-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Colony stimulating factor 3 receptor
CSF3R

Tests included:

Bi-directional sequencing of exons 14 and 17 of the CSF3R gene which includes detection of the common mutation T618I (also known as T595I).

Useful for:

CSF3R mutations are newly-identified genetic markers detected in 59% of chronic neutrophilic leukemia (CNL) or atypical chronic myeloid leukemia (aCML) that are useful for diagnosis and classification of these disorders. Identification of specific mutations may suggest the class of kinase inhibitors to which the tumor will be sensitive. Mutations are also detected in 30-80% of leukemia in patients with severe congenital neutropenia (SCN).

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

4 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Bone marrow

Alternate specimen volume:

2 mL

Alternate collection instructions:

Place 2 mL of bone marrow into a Lavender (EDTA), 4mL tube.
Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Required forms/information:

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.

Transport and stability:

Refrigerated (preferred)

Ambient -

Frozen -

Reason for rejection:

Improper label (unlabeled or mislabeled)
Clotted specimen
Improper anticoagulant or ratio
Improper storage/transport temperature

Performing lab:

Neogenomics: R- NX

Days set up:

Varies

TAT:

12 days

Method:

Molecular

Preauthorization:

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.

CPT codes:

81479

Subject to medical necessity (Y/N):

Yes

Other billing information:

Medical necessity

Molecular Medicare billing request

Date created:

10/18/2021

Revised date:

05/15/2024

Review date:

01/03/2024