Alpha-1 Antitrypsin
Alpha-1 Antitrypsin-14275
Alpha1-Protease Inhibitor
Detection of hereditary decreases in the production of α1-antitrypsin (α1AT). Decreased or nearly absent levels of α1AT can be a factor in chronic obstructive lung disease and liver disease. An increased prevalence of non-MM phenotypes is found with cryptogenic cirrhosis and with CAH. Cirrhosis in a child should raise consideration of α1AT deficiency or Wilson's disease. Diagnosis of inflammatory states, if elevated (eg, rheumatoid arthritis, bacterial infection, vasculitis, neoplasia).
Overnight fasting prior to sample collection is preferred
(Note: This volume does not allow for repeat testing.)
Immediatley following collection, mix sample by gently inverting 5 times
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Gold serum separator (SST) tube
Heparin plasma
Red/Lavender
- Allow sample to clot for a minimum of 30 minutes
- Spin within one (1) hour of collection
- Transfer serum/plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum/plasma
Lt Green PST
- Spin within two (2) hours of sample collection
|
Ambient (preferred) |
14 days |
|
Refrigerated |
14 days |
|
Frozen |
14 days |
|
Freeze/thaw cycles |
Stable x3 |
- Chylous serum
Immunologic
See report