Osmotic fragility, erythrocyte

Alphabetical Test listing

Osmotic fragility, erythrocyte-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

FRAGILITY, OSMOTIC (RBC)
Osmotic Fragility
RBC Fragility, Erythrocytes
Red Cell Fragility
Spherocytic Hemolytic Disease

Useful for:

Functional testing of red blood cell sensitivity to osmotic stress
Do not use to distinguish between spherocytes in hereditary spherocytosis and acquired autoimmune hemolytic anemia

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

5.0 mL

Minimum volume:

1.0 mL

Collection instructions:

Immediatley following collection, mix sample by inverting 8 - 10 times to prevent clotting.

Processing instructions:

Draw Mon - Wed ONLY
Refrigerate specimen within 30 minutes of collection

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Heparin whole blood

Alternate collection container:

Dk green heparin (Li or Na), no gel

Alternate collection instructions:

Immediately following collection, mix sample by inverting 5 - 10 times to prevent clotting.

Alternate transport container:

Dk green heparin (Li or Na), no gel

Transport and stability:

Refrigerated (strict) - 72 hours

Ambient - NO

Refrigerated - NO

Specimens must be received and testing performed by ARUP within 72 hours of collection.

Reason for rejection:

Grossly hemolyzed blood
Specimens received room temperature or frozen

Performing lab:

ARUP Laboratories Inc (2002257) via LabCorp (284205): R-2002257X

Days set up:

Mo - Fr

TAT:

4 - 6 days

Method:

Spectrophotometry

Reference ranges:

Within normal curve limits

Clinical information:

For patients with acute hemolysis, a normal red cell osmotic fragility test result cannot exclude an osmotic fragility abnormality since the osmotically labile cells may be hemolyzed and not present. Recommend testing during a state of prolonged homeostasis with stable hematocrit.

CPT codes:

85555

LOINC code:

Result 4667-2

Date created:

05/24/2019

Revised date:

12/18/2023

Review date:

12/18/2023