Disaccharidases, small bowel biopsy

Alphabetical Test listing

Disaccharidases, small bowel biopsy-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Specimen type:

Small bowel tissue

Volume:

9 mg

Minimum volume:

4 mg

Processing instructions:

Specimens should be frozen within 2 hours and maintained at a minimum of -80°C.

Transport container:

Sterile container or tissue cassettes

Transport and stability:

Frozen - 3 months

For specimens arriving thawed, or at the incorrect temperature, the client will be notified to inquire if the specimen should be rejected or run with a disclaimer.

Performing lab:

BioAgilytix via LabCorp (823304): R-NX

TAT:

31 - 89 days

Method:

Enzyme assay

Reference ranges:

Lactase: 13.00 – 105.00 µmole/min/g protein
Sucrase: 27.00 – 190.00 µmole/min/g protein
Maltase: 84.00 – 591.00 µmole/min/g protein
Palatinase: 4.00 – 67.00 µmole/min/g protein

Clinical information:

The enzymes collectively known as the mucosal disaccharidases (lactase, maltase, palatinase, and sucrase) are present in normal small intestine and fetal colon. Depending on the disease state, different enzymes are affected. A decrease in the enzyme activity of these disaccharidases has been noted in colonic adenomas, adenocarcinomas and malabsorption. Decreased disaccharidase activity is a good indicator of mucosal injury, with the exception of lactase.

CPT codes:

82657 x 4

LOINC code:

823305 Lactase 1942-2
823306 Sucrase 14178-8
823307 Maltase 1815-0
823308 Palatinase 14168-9

Date created:

05/30/2019

Revised date:

06/23/2021

Review date:

08/18/2022