Parvovirus B19 by IHC

Alphabetical Test listing

Test name:

Test number:

12376 - Technical only, 12379 - Technical & interpretation

Excellian order number:

LAB12376
LAB12379

Tests included:

Useful for:

Parvovirus is responsible for up to 10% of all non-malformed fetal deaths occurring between 10 and 24 weeks of gestation.¹
Fetuses dying of this infection may or may not be hydropic. Antibody usefulness has been documented even in cases of extreme autolysis
Parvovirus B19 can infect and lyse erythroid precursors causing severe anemia in patients with immunodeficiency and transient aplastic crisis in patients with chronic hemolytic anemia²
Characteristic nuclear inclusions (Lantern cells) can be difficult to visualize
Parvovirus B19 has been implicated in certain viral exanthems including Fifths disease (erythema infectiosum) and papular purpuric gloves and socks syndrome (PPGSS). Staining can be demonstrated in infected dermal endothelial cells, keratinocytes and sweat glands³
Parvovirus B19 has been reported to cause hemophagocytic syndrome and lymph node changes resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease)

Specimen type:

Tissue

Processing instructions:

Submit a formalin-fixed, paraffin embedded tissue block

Transport container:

Formalin-fixed, paraffin embedded (FFPE) tissue block

Alternate transport container:

FFPE tissue section mounted on a charged, unstained slide

Transport and stability:

Ambient (preferred)

Reason for rejection:

Performing lab:

AHL - Immunohistochemistry

Days set up:

Mo - Fr

TAT:

1 - 2 days

Method:

Immunohistochemical staining and microscopic examination

Reference ranges:

If requested, an interpretive report will be provided

Clinical information:

Specifications:

Antibody to VP1 and VP2 capsid proteins of parvovirus B19 purified from human plasma

Staining pattern:

References

Wright C, et al: Fetal Pathology in Intrauterine Death due to Parvovirus B19 infection. British J. AP, Feb 1996, Vol 103, pp 133-136.
Liu W, et al: Human Parvovirus B19 in Bone marrows from Adults with Acquired Immunodeficiency Syndrome: A comparative Antibody Using In Situ Hybridization and Immunohistochemistry. Human Pathology 28(7)760-6, July 1997.
Aractingi S. et al: Immunohistochemical and Virological study of skin in the papular purpuric gloves and socks syndrome. British J. H Derm. 135(4):599-602, Oct, 1996.
Yuen Y et al: Parvovirus B19 Associated Hemophagocytic Syndrome with Lymphadenopathy resembling histiocytic necrotizing lymphadenitis (Kikuchi's disease). British J. of NEM. 96(4):868-71, 1997 March.

CPT codes:

88342 - 1st stain
88341 - each additional stain

Date created:

08/07/2017

Revised date:

10/19/2018

Review date:

01/12/2024