Cytomegalovirus (CMV) genotype

Alphabetical Test listing

Cytomegalovirus (CMV) genotype-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Cidofovir Resistance Genotyping
CMV Drug Resistance Genotyping
Foscarnet Resistance Genotyping
Ganciclovir Resistance Genotyping
UL54
UL97

Useful for:

Treatment of CMV diseases includes three licensed drugs: ganciclovir, foscarnet and cidofovir. All three drugs inhibit the viral DNA polymerase through various mechanisms. Over time, as CMV makes copies of itself, the virus can change its structure. These changes may make CMV resistant to the effects of antiviral drugs. Therefore, it is important to detect resistance as quickly and accurately as possible for proper management of CMV infection.

Specimen type:

EDTA plasma

Collection container:

Lavender (EDTA), 4mL

Volume:

1.0 mL

Minimum volume:

0.3 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting

Processing instructions:

Spin
Transfer plasma to a Screw-cap polypropylene frozen transport vial/tube - 4mL (LabCorp), labelled as EDTA plasma, within two (2) hours of sample collection
Freeze

Avoid repeated freezing and thawing of specimen.

Transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Alternate specimen type:

Cerebrospinal fluid (CSF)
Bronchial lavage/wash

Alternate collection container:

Sterile vial/container

Alternate transport container:

Sterile vial/container

Transport and stability:

Plasma/CSF:

Frozen

BAL:

Refrigerated

Performing lab:

Quest Diagnostics Infectious Disease via LabCorp (009985): R-NX

Days set up:

Mo, We

TAT:

5 - 8 days

Method:

DNA Sequencing Polymerase Chain Reaction (PCR)

Reference ranges:

An interpretive report will be provided

CPT codes:

87910

Date created:

05/20/2019

Revised date:

05/20/2019

Review date:

03/17/2022