Uroporphyrinogen decarboxylase, whole blood

Alphabetical Test listing

Uroporphyrinogen decarboxylase, whole blood-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Erythrohepatic Uroporphyria (EHUP)
Hepatoerythropoietic Porphyria (HEP)
Porphyria Cutanea Tarda (PCT)

Useful for:

Preferred test for the confirmation of a diagnosis of porphyria cutanea tarda type II and hepatoerythropoietic porphyria.

Patient preparation information:

Patient should abstain from alcohol for 24 hours.
- Abstinence is essential for at least 24 hours as alcohol suppresses enzyme activity for 24 hours after ingestion.

Specimen type:

Sodium heparin (Na hep) whole blood

Collection container:

Dk green Sodium heparin (Na hep), no gel

Volume:

4.0 mL

Minimum volume:

3.0 mL

Collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

Transport container:

Dk green Sodium heparin (Na hep), no gel

Alternate specimen type:

EDTA whole blood
Lithium heparin (Li hep) whole blood

Alternate collection container:

Lavender (EDTA), 4mL

Dk green Lithium heparin (Li hep), no gel

Alternate transport container:

Lavender (EDTA), 4mL

Dk green Lithium heparin (Li hep), no gel

Transport and stability:

Refrigerated (preferred) – 14 days

Ambient – 7 days

Frozen – NO

Specimen retention time:

2 weeks

Reason for rejection:

Gross hemolysis

Performing lab:

Mayo Clinic Laboratories (UPGD): R-NX

Days set up:

Tu, Th

TAT:

7 days

Method:

High-Performance Liquid Chromatography (HPLC)/Incubation of lysed erythrocytes

Reference ranges:

≥1.0 Relative units (RU) - normal

0.80 - 0.99 Relative units (RU) - indeterminate

<0.80 Relative units (RU) - indicative of PCT type II

Cautions:

Alcohol ingestion within 24 hours of specimen collection may lead to a false-positive result.

CPT codes:

82657

Date created:

07/23/2021

Revised date:

01/02/2024

Review date:

01/02/2024