Liver-Kidney Microsomal (LKM) antibodies
Liver-Kidney Microsomal (LKM) antibodies-13414
LKM-1 antibodies
The detection of LKM-1 IgG Antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH2).
Immediately following collection, thoroughly mix sample by gently inverting 5 times
- Allow sample to clot for a minimum of 30 minutes
- Spin within two (2) hours of sample collection
Gold serum separator (SST) tube
- Allow sample to clot
- Spin
- Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum, within two (2) hours of sample collection
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles: stable x 4
- Hemolysis
- Lipemia
- Gross bacterial contamination
- Heat treated
- Sample with preservative added
Enzyme-linked immunosorbent assay (ELISA)
Negative: 0.0 - 20.0
Equivocal: 20.1 - 24.9
Positive: >24.9
The detection of LKM-1 IgG Antibodies is an aid in the diagnosis of autoimmune hepatitis, type 2 (AIH2). LKM Antibodies are markers of AIH2 which usually begins in childhood and generally affects children under 18 years of age. LKM antibodies are associated with a more serious progression of the disease. The disease is most common between the ages of 2-14 and is more frequent in females than males (8:1). LKM-1 antibodies have been reported in up to 8% of patients with chronic HCV infection.