CLL progressive panel by FISH
CLL progressive panel by FISH-Order the individual components; 4280H (blood) or 4280G (bone marrow)
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
TP53
CLL
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
17p13.1 deletion
TP53 deletion
11p22 deletion
- ATM
- TP53
The CLL Progressive Panel is useful for detecting the poor/adverse cytogenetics FISH abnormalities for follow-up CLL/SLL cases.
Only one specimen tube is required to perform all ordered cytogenetics testing.
The more testing ordered, the closer to the optimal volume requirements is preferred.
Dk green Sodium heparin (Na hep), no gel
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
Bone marrow
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
Bone marrow:
Sterile vial/tube
Dk green Sodium heparin (Na hep), no gel
EDTA whole blood:
Lavender (EDTA), 4mL
- AHL Cytogenetics oncology request
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Improper blood/anticoagulant ratio
- Delay in transport
- Improper storage
- Leaking container
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation.
Deletion of ATM or TP53 are classified as unfavorable cytogenetics prognostic indicators in CLL/SLL.