HLA B*58:01, Allopurinol hypersensitivity
HLA B*58:01, Allopurinol hypersensitivity-994
B58
B5801
HLA B*58:01
HLA B58
Allopurinol associated SCAR (severe cutaneous adverse drug reaction) including Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) has been shown to be associated with the human leukocyte antigen (HLA) B*58:01 of the major histocompatibility complex (MHC). The MHC family of genes codes for a highly variable set of cell surface glycoproteins (HLAs) that play a critical role in presenting antigens to T-cell receptors to elicit an immune response. The presence of the HLA B*58:01 allele increases the susceptibility to allopurinol SCAR in several populations studied.
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting
- Do not spin
- Submit original tube
Lavender (EDTA), 10mL
Molecular Medicare billing request
Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.
Ambient (preferred)
Refrigerated (OK)
- Hemolysis
- Clotted specimen
- Insufficient volume of DNA
Next Generation Sequencing (NGS)
An interpretive report will be provided
Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medicare billing request form to notify us of the need for Allina Health Laboratory to bill insurance.