Trisomy 12 by FISH

Alphabetical Test listing

Trisomy 12 by FISH-4280H (blood) or 4280G (bone marrow)

  
Trisomy 12 by FISH
  
4280H (blood) or 4280G (bone marrow)
  
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
  
Del13/CEP12
  
CLL
CLL Full Panel
CLL Prognostic Panel
Chronic Lymphocytic Leukemia
SLL
Small Lymphocytic lymphoma
Trisomy 12
+12
  

Trisomy 12 is a recurring abnormality of Chronic Lymphocytic Leukemia (CLL)/ Small Lymphocytic lymphoma (SLL).

This test can be ordered individually or as part of a CLL Full Panel or CLL Prognostic Panel (See the individual panel tests for more details).

  
Sodium heparin (Na hep) whole blood
  
  
5 mL
  
2 mL
  

Only one specimen tube is required to perform all ordered cytogenetics testing.

The more testing ordered, the closer to the optimal volume requirements is preferred.

  

Dk green Sodium heparin (Na hep), no gel

  
Bone marrow
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
  

EDTA whole blood:

Lavender (EDTA), 4mL

  
Bone marrow: 10 mL (minimum 5 mL)
  

Bone marrow:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  

Bone marrow:

Sterile vial/tube

Dk green Sodium heparin (Na hep), no gel

 

EDTA whole blood (not recommended):

Lavender (EDTA), 4mL

  
  • AHL Cytogenetics oncology request
  

Ambient

  
Pellets - 2 years
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Leaking container
  
AHL - Cytogenetics: X
  
As needed
  
5 - 7 days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation.

A trisomy 12 finding is classified as a neutral cytogenetics prognostic indicator in CLL/SLL according to NCCN.

  
88271 x 2
88275
  
Yes
  
03/18/2021
  
04/06/2021