Acetylcholine receptor (AChR) binding Ab

Alphabetical Test listing

Acetylcholine receptor (AChR) binding Ab-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

AChR binding antibodies
ACRAB
Myasthenia gravis antibody

Useful for:

In vitro diagnostic semiquantitative determination of autoantibodies against the acetylcholine receptor in human serum and plasma. This assay is the primary test for confirming the diagnosis of acquired Myasthenia gravis.

Patient preparation information:

No isotopes administered 24 hours prior to venipuncture.

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

1.0 mL

Minimum volume:

0.3 mL

Collection instructions:

Immediatley following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin

Transport container:

Gold serum separator (SST) tube

Alternate collection container:

Red serum vial/tube - 5 mL

Alternate processing instructions:

Allow sample to clot
Spin
Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as "serum" within 45 minutes of collection.

Alternate transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Transport and stability:

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cylces - 3

Reason for rejection:

Gross hemolysis
Gross icterus
Gross lipemia

Performing lab:

LabCorp Burlington (085902): R-NX

Days set up:

Mn - Fr

TAT:

2 - 4 days

Method:

This assay measures antibodies that precipitate solubilized muscle AChR that has been complexed with radiolabeled alpha-bungarotoxin (αBTX).
Antibodies that bind to the receptor regions that are not sterically blocked by the αBTX are detected.

Reference ranges:

Negative: 0.00 - 0.24 nmol/L

CPT codes:

83519

LOINC code:

Result 11034-6

Date created:

11/30/2001

Revised date:

10/26/2020

Review date:

10/26/2020