CD43 by IHC

Alphabetical Test listing

CD43 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
CD43 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Leu22
  

All IHC stains will include a positive control tissue

  
  • Approximately 90% of peripheral T cell lymphomas are positive for Leu22
  • However, its disadvantage is that 30-40% of B cell NHL are also Leu22 positive
  • Approximately 90% of myeloid leukemias are positive for Leu22
  • The combination of CD20 positive and Leu22 positive lymphoid populations is diagnostic of malignant lymphoma
  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • CD43 reacts with a membrane/cytoplasmic antigen expressed by T cells and myeloid lineage cells

Staining pattern

  • Cell membrane based

References

  1. Ngan et. al.: Immunophenotypic Diagnosis of Non-Hodgkin's Lymphoma in Paraffin Sections: Co-expression of Leu22 and L26 Antigens Correlates with Malignant Histology; American Journal of Clinical Pathology 91:579-583, 1989.
  
88342 - 1st stain
88341 - each additional stain
  
06/16/2017
  
10/18/2018
  
10/02/2020