Therapeutic drug management
Trough levels are most reproducible
Spin and separate
Dk green heparin (Li or Na), no gel
Spin and separate
Refrigerated (preferred)
Ambient (OK) - 3 days
Frozen (OK)
Liquid Chromatography/Tandem Mass Spectrometry (LC/MS/MS)
Expected steady state concentrations of risperidone and 9-hydroxyrisperidone (combined total) in patients receiving recommended daily dosages:
10 - 120 ng/mL