Fungitell, serum

Alphabetical Test listing

Fungitell, serum-13641

  
Fungitell, serum
  
13641
  
LAB13641
  
FUNGITELL
  
Fungitell B-D Glucan
Fungitell-D-glucan assay
  
The Fungitell β-D Glucan assay is indicated for the presumptive diagnosis of invasive fungal disease through detection of elevated levels of (1,3)- β-D-glucan in serum.
  
Serum
  
  
2.0 mL
  
0.2 mL (pediatric)
  
  • Original tube requested. 
  • Spin and freeze in the serum separator (SST) tube.
  • Do not transfer the serum to an aliquot tube.
  

Gold serum separator (SST) tube

  
Frozen (preferred) - 30 days
Refrigerated - 30 days
Ambient - 30 days
  
  • Lipemic specimen 
  • Icteric specimen
  • Hemolyzed specimen
  
Viracor Eurofins (1710) via LabCorp (284526): R-LC
  
Mo - Fr
  
1 - 4 days
  

The assay is based upon a modification of the Limulus Amebocyte Lysate (LAL) pathway.

  

< 60 pg/mL

  
Normal human serum contains low levels of (1,3)- β-D glucan, typically 10 to 40 pg/mL, presumably from commensal yeasts present in the alimentary canal and gastrointestinal tract. However, (1,3)- β-D-glucan is sloughed from the cell walls during the life cycle of most pathogenic fungi. Thus, monitoring serum for evidence of elevated and rising levels of (1,3)- β-D-glucan provides a convenient surrogate marker for invasive fungal disease.
 
The Fungitell ß-D Glucan assay detects (1,3)- β-D-glucan from the following pathogens: Candida spp., Acremonium, Aspergillus spp., Coccidioides immitis, Fusarium spp., Histoplasma capsulatum, Trichosporon spp., Sporothrix schenckii, Saccharomyces cerevisiae, and Pneumocystis jiroveci.
 
The Fungitell ß-D Glucan assay does not detect certain fungal species such as the genus Cryptococcus, which produces very low levels of (1,3)- β-D-glucan, nor the Zygomycetes, such as Absidia, Mucor, and Rhizopus, which are not known to produce (1,3)- β-D-glucan. Studies indicate Blastomyces dermatitidis is usually not detected due to little (1,3)- β-D-glucan produced in the yeast phase.
  
87449
  
Result 42176-8
  
04/29/2019
  
11/08/2019
  
02/22/2021