Evaluation of vitamin C deficiency
Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times to prevent clotting
Frozen (strict) - 14 days
Refrigerated - NO
Ambient - NO
Liquid chromatography-tandem mass spectrometry (LC/MS-MS)
0.4 - 2.0 mg/dL
Serum levels of vitamin C are an adequate measurement of clinical status. Vitamin C is a cofactor for protocollagen hydroxylase; it promotes the conversion of tropocollagen to collagen. Low values occur in scurvy, malabsorption, alcoholism, pregnancy, hyperthyroidism, and renal failure. Smokers have lower levels than nonsmokers. Patients with scurvy have values <0.2 mg/dL.
Principal clinical findings in scurvy include bleeding gums, petechiae, follicular hyperkeratosis, perifollicular hemorrhages beginning on the lower thighs, muscle aches, easy fatiguability, and emotional changes.