Vitamin C

Alphabetical Test listing

Vitamin C-13314

Vitamin C
Ascorbic acid
C, vitamin

Evaluation of vitamin C deficiency

Lithium heparin (Li hep) plasma
1.0 mL
0.5 mL

Immediately following collection, mix sample thoroughly by gentle inverting 8 - 10 times to prevent clotting

  1. Spin immediately after venipuncture
  2. Transfer plasma to an  Amber screw-cap polypropylene frozen transport tube/vial - 4mL (LabCorp), labelled as Lithium heparin plasma
  3. Freeze within 4 hours of separation



Frozen (strict) - 14 days

Refrigerated - NO

Ambient - NO

  • Anticoagulants other than lithium heparin
  • Specimen not protected from light
LabCorp Burlington (001805): R-LC
Su - Fr
3 - 5 days

Liquid chromatography-tandem mass spectrometry (LC/MS-MS)


0.4 - 2.0 mg/dL


Serum levels of vitamin C are an adequate measurement of clinical status. Vitamin C is a cofactor for protocollagen hydroxylase; it promotes the conversion of tropocollagen to collagen. Low values occur in scurvy, malabsorption, alcoholism, pregnancy, hyperthyroidism, and renal failure. Smokers have lower levels than nonsmokers. Patients with scurvy have values <0.2 mg/dL.

Principal clinical findings in scurvy include bleeding gums, petechiae, follicular hyperkeratosis, perifollicular hemorrhages beginning on the lower thighs, muscle aches, easy fatiguability, and emotional changes.

Result 1903-4