Celiac cascade

Alphabetical Test listing

Celiac cascade-12442

  
Celiac cascade
  
12442
  
LAB12442
  
CELC
  
Celiac disease panel
Celiac
TTG
DGP
  
  • Total IgA
    • If Normal or Elevated: TTg IgA is performed at an additional charge
    • If TTG IgA result is Equivocal, the following will be performed
      at an additional charge:
      • Deamidated Gliadin IgA
      • Endomysial IgA
    • If Total IgA is low but ≥7.0: TTg IgA, TTg IgG, and Deamidated Gliadin IgA and IgG are performed at additional charge
    • If Total IgA is deficient < 7.0: TTg IgG and Deamidated Gliadin IgG are performed at additional charge
  

Celiac disease is characterized by gluten intolerance leading to a chronic malabsorptive disorder due to inflammation of the intestinal mucosa and flattening of the epithelium. Autoantibodies associated with celiac disease include; IgA anti-endomysial antibodies, IgG and IgA anti-gliadin antibodies and anti-reticulin antibodies. Several studies have demonstrated that IgA anti-endomysial tests have greater than 99% specificity for celiac disease with a greater sensitivity than anti-gliadin and anti-reticulin assays.

  
Serum
  
  
1.0 mL
  
0.5 mL
  

Spin

  

Gold serum separator (SST) tube

  
  

Spin and separate

  
  

Refrigerated (preferred) - 7 days

Frozen - 14 days

Ambient - NO

  
  • Improper labels (unlabeled or mislabeled)
  • Hemolysis (some procedures)
  • Improper anticoagulant or ratio
    • Heparinized plasma is not acceptable
  • Delay in transport
  • Improper storage temperature affecting results
  • Improper container
  • Leaking container resulting in compromised specimen
  • Quantity not sufficient (QNS)
  •  
  
AHL - Immunology: J
  
Mo, We, Fr
  
3 - 5 days
  

Enzyme-linked immunosorbent assay (ELISA)

  

IgA total
Adult: 50 – 450 mg/dL 

TTg IgA
Negative: <4.0 U/mL
Weak positive: 4.0 - 10.0 U/mL
Strong positive: >10 U/mL

TTg IgG
Negative: <6 U/mL
Weak positive: 6.0 - 9.0 U/mL
Strong positive: >9 U/mL

Gliadin IgA
Negative: < 20 U/mL
Weak positive: 20 – 30 U/mL
Strong positive: >30 U/mL

  

 

 

  
82784 - IgA

Additional CPT codes (if appropriate):"83516 - Gliadin IgA
83516 - Gliadin IgG
83516 - Tissue Transglutaminase IgA
83516 - Tissue Transglutaminase IgG
  
04/09/2014
  
12/13/2019
  
02/17/2020