Submit a formalin-fixed, paraffin embedded tissue block
FFPE tissue block
Tissue section mounted on a charged, unstained slide
Immunohistochemical staining and microscopic examination
If requested, an interpretive report will be provided
SMARCA4 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A, member 4) encodes BRG1, a protein of the WSI/SNF complex involved in chromatic remodeling. SMARCA4-deficient neoplasms have undifferentiated, often rhabdoid morphology and demonstrate loss of BRG1 immunohistochemical nuclear expression.
Nuclear staining in normal tissues. Loss of nuclear staining is present in SMARCA4/BRG1 deficient tumors.
Small cell carcinoma of the ovary hypercalcemic type with loss of nuclear staining; lymphocytes and endothelial cells serve as positive internal controls