MTHFR C677T assay

Alphabetical Test listing

MTHFR C677T assay-5919

  
MTHFR C677T assay
  
5919
  
LAB5919
  
MTL
  
Methylenetetrahydrofolate reductase
  
EDTA whole blood
  
  
3.0 mL
  

Only one (1) tube needs to be drawn for any combination of the following tests:

  • Calreticulin Exon 9 Assay
  • Factor V Leiden Mutation
  • Factor 2 Mutation
  • Hereditary Hemochromatosis
  • JAK2 V617F Mutation Detection
  • MTHFR C677T assay
  

Lavender (EDTA), 4mL

 

 

 

  
ACD whole blood
Sodium citrate (Na cit) whole blood
  

Lt blue Sodium citrate (NaCit)

Yellow ACD (A or B)

 

  

Lt blue Sodium citrate (NaCit)

Yellow ACD (A or B)

  

Molecular Medicare billing request

Hospital clients submitting a request for this assay on an outpatient with Medicare should complete and submit a Molecular Medical billing request form along with the sample.

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed
  

Ambient (preferred)

Refrigerated

  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Improper blood/anticoagulant ratio
  • Delay in transport
  • Improper storage
  • Interfering substances
  
AHL - Molecular Diagnostics: D
  
Varies
  
8 days
  

Polymerase Chain Reaction (PCR) with RFLP analysis

  

Negative

  

Due to lack of established clinical utility, MTHFR genotyping is no longer covered by most insurances. MTHFR genotyping should not be ordered as a part of the clinical evaluation for thrombophilia or recurrent pregnancy loss; fasting homocysteine is the preferred biomarker in these cases. The use of MTHFR genotyping should be restricted to symptomatic patients who have an increased basal homocysteine. The lack of evidence to support MTHFR variant testing is detailed in a 2013 practice guideline from the American College of Medical Genetics and Genomics (ACMG). MTHFR genotyping is considered investigational for nutritional, mental health or pharmacogenic assessment. The indication for testing must be provided at the time of order. This is a genetic test and needs to be performed only once in a lifetime

  
This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
  
81291
  
Yes
  
  
10/02/2003
  
07/27/2018
  
03/13/2020