Treponema pallidum by IHC

Alphabetical Test listing

Treponema pallidum by IHC-12376 - Technical only, 12379 - Technical & interpretation

Treponema pallidum by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • T Pallidum is used to identify syphilis in tissue based material
  • This stain is an important adjunct in the identification of syphilis, since the organism is refractory to culture, and histochemical stains are difficult to interpret

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • T Pallidum identifies the causative agent of syphilis

 Staining pattern

  • Red, corkscrew bacterial pattern of staining (a red chromogen is used with this antibody)










  1. Guarner J et al: Congenital syphilis in a newborn: an immunopathologic study. Mod Pathol 1999; 12:82-87.
  2. Beckett JH et al: Immunoperoxidase localization of treponema pallidum: its use in formaldehyde-fixed and paraffin-embedded tissue sections. Arch Pathol Lab med 1979 Mar; 103(3): 135-8.
88342 - 1st stain
88341 - each additional stain