Erythrocytosis evaluation, whole blood

Alphabetical Test listing

Erythrocytosis evaluation, whole blood-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

BPGM
Chuvash Polycythemia
Congenital erythrocytosis
Congenital polycythemia
EGLN1
EPAS1
EPOR
Erythrocytosis
Familial erythrocytosis
Familial polycythemia
PFCP
Hereditary erythrocytosis
Hereditary polycythemia
HIF2
High oxygen affinity hemoglobin
HOA hemoglobin
PHD2
Polycythaemia
Polycythemia
Primary familial erythrocytosis
Primary familial polycythemia
VHL

Tests included:

Hb Variant, A2 and F Quantitation
HPLC Hb Variant
Hb Variant by Mass Spec

Useful for:

Definitive, comprehensive, and economical evaluation of an individual with JAK2-negative erythrocytosis associated with lifelong sustained increased hemoglobin or hematocrit

Specimen type:

EDTA whole blood

Collection container:

Lavender (EDTA), 4mL

Volume:

5.0 mL

Minimum volume:

2.5 mL

Collection instructions:

Immediatley following collection, mix samples thoroughly by gentle inverting 8 - 10 times, to prevent clotting

Processing instructions:

Refrigerate specimens immediately after collection
Do not aliquot

Transport container:

Lavender (EDTA), 4mL

Alternate specimen type:

Yellow ACD-B whole blood
Sodium heparin (Na hep) whole blood

Alternate collection container:

Yellow ACD-solution B (ACD-B) vial/tube

Dk green Sodium heparin (Na hep), no gel

Transport and stability:

Refrigerated – 7 days

Ambient - NO

Frozen - NO

Specimen retention time:

28 days

Reason for rejection:

Gross hemolysis

Performing lab:

Mayo Clinic Laboratories (REVE2): R-NX

Days set up:

Mo - Sa

TAT:

3 - 25 days

Method:

REVEI, REVE0: Medical Interpretation
HGBCE: Capillary electrophoresis
HPLC: Cation Exchange/High Performance Liquid Chromatography (HPLC)
MASS: Mass Spectrometry (MS)
IEF: Isoelectric Focusing
SDEX: Hemoglobin S Solubility
HEMP: Polymerase Chain Reaction (PCR) Amplification/Sanger Sequence Analysis
HPFH: Flow Cytometry
UNHB Isopropanol and Heat Stability
ATHAL: Alpha-Globin Gene Analysis, Varies
WASQR, WBSQR, WGSQR, BPGMM: Polymerase Chain Reaction (PCR)/Sanger Sequencing
WBDDR: Polymerase Chain Reaction (PCR) Analysis/Multiplex Ligation-Dependent Probe Amplification (MLPA)
VHLE: Polymerase Chain Reaction (PCR) followed by DNA Sequence Analysis

Reference ranges:

Definitive results and an interpretive report will be provided.

Clinical information:

Erythrocytosis Evaluation.indd (mayocliniclabs.com)

CPT codes:

83020 - Hemoglobin Electrophoresis
83021 - HPLC Hb Variant
83789 - Hemoglobin Variant by Mass Spectroscopy (MS), Blood

Additional CPT codes (if appropriate):
83068
82664
88184

Date created:

08/12/2021

Revised date:

12/26/2022

Review date:

01/02/2024