Antiscleroderma-70 antibodies

Alphabetical Test listing

Antiscleroderma-70 antibodies-13355

Antiscleroderma-70 antibodies
Anti-Scl 70

Semiquantitative result of IgG class


Differential diagnosis of scleroderma (progressive systemic sclerosis)

1.0 mL
0.5 mL
Submission of the minimum volume does not allow for repeat testing

Immediatley following collection, mix sample by gently inverting 5 times

  1. Allow sample to clot for a minimum of 30 minutes
  2. Spin within two (2) hours of sample collection

Gold serum separator (SST) tube

  1. Allow sample to clot
  2. Spin
  3. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as serum, within two (2) hours of sample collection

Ambient (preferred) - 14 days

Refrigerated - 14 days

Frozen - 14 days


Hemolysis, icterus, lipemia, gross bacterial contamination

LabCorp Burlington (018705): R-LC
Mo - Sa
1 - 3 days

Multiplex flow immunoassay


0.0 - 0.9 AI


Scl-70 antibody is seen in 20% of patients with scleroderma, and in some patients with CREST syndrome (calcinosis, Raynaud, esophageal dysfunction, sclerodactyly, telangiectasia). These syndromes are also associated with a high frequency of speckled pattern immunofluorescent antinuclear antibody tests. Scl-70 may identify a subset of scleroderma patients with severe skin, joint, and lung disease. In addition, the presence of Scl-70 in Raynaud phenomenon may indicate a poor prognosis.

Result 27416-7