Vanillylmandelic acid, random urine

Alphabetical Test listing

Vanillylmandelic acid, random urine-994

Vanillylmandelic acid, random urine
3-Methoxy-4-hydroxymandelic acid

Use for patients where 24-hour urine collection is difficult (eg, pediatric patients), as a 24-hour urine collection is preferable.



Patient should avoid salicylates, caffeine, phenothiazine, and antihypertension agents, as well as coffee, tea, chocolate, fruit (especially bananas and any vanilla-containing substances) for 72 hours prior to collection.

Urine, random
10 mL
1.0 mL

Transfer 10mL random urine to a Transfer vial/tube with cap - 12mL (LabCorp)


Ambient (preferred) - 7 days

Refrigerated - 14 days

Frozen - 14 days

Freeze/thaw cycles - stable x3

LabCorp Burlington (123208): R-NX
Mo - Fr
4 - 7 days

Liquid chromatography/tandem mass spectrometry (LC/MS-MS)


VMA:creatinine ratio

< 2 years:      0.0−18.8 mg/g creatinine

2 - 4 years:    0.0−11.0 mg/g creatinine

5 - 9 years:    0.0−8.3 mg/g creatinine

10 - 19 years: 0.0−8.2 mg/g creatinine

> 19 years:     0.0−6.0 mg/g creatinine


Pediatric testing for the evaluation of hypertension; diagnose and follow up neuroblastoma, ganglioneuroma, and ganglioneuroblastoma. Most neuroblastoma patients excrete excess HVA in 24-hour collections. If VMA and HVA are both used in work-up, up to 80% of all cases will be detected.

Some neuroblastoma patients are positive for urinary homovanillic acid abnormality but do not excrete increased VMA. Twenty percent to 32% of patients with neuroblastoma do not have elevation of VMA. Many will have other laboratory abnormalities such as increased metanephrines, homovanillic acid (HVA), or dopamine.