ETV6/RUNX1 by FISH

Alphabetical Test listing

ETV6/RUNX1 by FISH-4280J (malignant tissue)

  
ETV6/RUNX1 by FISH
  
4280J (malignant tissue)
  
LAB4280J - CYTOGENETICS MALIGNANT TISSUE STUDIES
  
ETV6/RUNX1 FISH
  
Acute Lymphoblastic Leukemia/lymphoma
B-Lymphoblastic Leukemia/lymphoma
B-ALL
B-cell ALL
FISH
Fluorescence In Situ Hybridization
iAMP21 (amplification RUNX1)
TEL/AML
t(12;21)
  

ETV6/RUNX1 or TEL/AML or t(12;21), or amplification of RUNX1 (iAMP21) rearrangements, are recurring abnormalities in B-cell ALL. According to current NCCN B-ALL guidelines, ETV6/RUNX1 or TEL/AML or t(12;21) abnormalities are classified as a good cytogenetic risk factor, and amplification of RUNX1 (iAMP21) is classified as a poor cytogenetic risk factor.

This test can be ordered individually or as part of the B-cell ALL FISH Panels. See the panel tests for more details.

  
Lymph Node (fresh tissue)
  

Sterile cup or tube

  
5mm3 tissue
5ml
  

Place specimen in a sterile cup/tube with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline.

  

Submit entire specimen

  

Sterile specimen cup/tube

  
Touch prep slides
  

Touch prep slides

  

AHL Cytogenetics Oncology Request

  

Ambient

  
Slides - 6 months
Blocks will be returned post reporting
  
  • Improper label (unlabeled or mislabeled)
  • Slides broken beyond repair
  • Heavy metal fixatives are unacceptable
  
AHL - Cytogenetics: X
  
Mo - Fr
  
5 business days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation

  
Fresh Tissue/Touch Prep:
88271 x 2
88275
88291
  
Yes
  
  
09/13/2022