MLL (CDKN2A) by FISH

Alphabetical Test listing

MLL (CDKN2A) by FISH-4280G (bone marrow) or 4280H (blood)

  
MLL (CDKN2A) by FISH
  
4280G (bone marrow) or 4280H (blood)
  
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES
  
MLL
  
Acute Lymphoblastic Leukemia/lymphoma
B-ALL
B-cell ALL
FISH
Fluorescence in situ hybridization
Mixed Lineage Leukemia
MDS
Myelodysplastic syndrome
t(11q23;?)
AML
Acute Myeloid Leukemia
CDKN2A
  

MLL (CDKN2A) or t(11q23;?) rearrangements are recurring abnormalities in AML, B-cell ALL and MDS. According to current NCCN AML guidelines, these abnormalities are classified as adverse cytogenetic risk factors, however, a t(9;11) is classified as an intermediate risk factor.  All MLL rearrangements are classified as intermediate cytogenetic risk factors in MDS. 

This test can be ordered individually or as part of the B-ALL or MDS FISH Panels. See the panel tests for more details.

  
Bone Marrow aspirate
  

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

  

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel

  
5 mL
  
3 mL
  

Transfer aspirate from syringe to transport container. 

  

Submit entire specimen unspun.

  
  
Bone marrow core
Sodium heparinized whole blood
Touch Prep slides
  

Bone marrow core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

Whole blood:

Dk green Sodium heparin (Na hep), no gel - 4mL

  
Bone marrow core: 10 mm
Whole blood: 5 mL
  

Bone marrow core:

Sterile tube or cup

or 

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  

Submit entire specimen unspun

  

Bone marrow core:

Sterile tube/cup

Whole blood:

Dk green Sodium heparin (Na hep), no gel

  

AHL Cytogenetics Oncology Requisition

  

Ambient

  
Specimens retained until completion of all testing
  
  • Improper label (unlabeled or mislabeled)
  • Wrong container (anticoagulant or solution)
  • Delay in transport
  • Improper storage
  • Leaking container
  • Slides broken beyond repair
  
AHL - Cytogenetics: X
  
Mo - Fr
  
5 business days
  

Fluorescence in situ hybridization (FISH)

  

Normal or Abnormal with interpretation

 

  
88271 x 2
88275
88291
  
Yes
  
  
03/23/2021
  
09/08/2022
  
09/12/2022