SeroNeg Rad x 3 profile

Alphabetical Test listing

SeroNeg Rad x 3 profile-994

  
SeroNeg Rad x 3 profile
  
994
  
LAB994
  
MSO
  
  • 14-3-3 eta protein
  • Anti-CEP-1 Ab
  • Anti-Sa Ab
  

SeroNeg RAdx3 is a diagnostic and prognostic panel for Rheumatoid Arthritis designed to complement traditional RF and Anti-CCP testing.

This profile, consisting of 14-3-3 eta protein, Anti-CEP-1 Ab and Anti-Sa Ab, enhances the diagnosis of established or early RA (in individuals seronegative for RF and Anti-CCP Ab) and also helps predict disease severity.

Decrease in 14-3-3eta and/or Anti-Sa Ab with treatment is associated with less radiographic progression. The presence of Anti-CEP1 and Anti-CCP Antibodies suggests the imminent progression of pre-clinical RA into clinical RA.

  
Serum
  
  
3.0 mL
  
  1. Spin within one (1) hour of specimen collection.
  2. Transfer serum to a Transfer vial/tube with cap - 12mL (LabCorp)
  
  

Refrigerated (preferred) – 14 days

Ambient – 7 days

Frozen – 60 days

Freeze/thaw cycles - stable x1

  
  • Grossly hemolyzed
  • Bacterial contamination
  • Lipemic specimen
  • Icteric specimen
  • Non-serum specimen types
  
LabCorp (520209): R-NX
  
Once per week
  
7 - 10 days
  

Enzyme-linked Immunosorbent Assay (ELISA)

  

14.3.3 ETA, Rheum. Arthritis

    Negative: <0.20 ng/mL

    Weak positive: 0.20 - 0.39 ng/mL

    Moderate positive: 0.40 - 0.79 ng/mL

    Strong positive: >0.79 ng/mL

Anti-CEP-1 Ab, IgG; Units

    Negative: <20

    Weak positive: 20 - 39

    Moderate positive: 40 - 80

    Strong positive: >80

Anti-Sa Ab, IgG; Units

    Negative: <20

    Weak positive: 20 - 39

    Moderate positive: 40 - 80

    Strong positive: >80

  
83520 x 3
  
06/14/2021
  
06/15/2021