FGFR1 by FISH

Alphabetical Test listing

FGFR1 by FISH-4280G (bone marrow) or 4280H (blood)

Test name:

FGFR1 by FISH

Test number:

4280G (bone marrow) or 4280H (blood)

Excellian order number:

LAB4280G - CYTOGENETIC BONE MARROW STUDIES
LAB4280H - CYTOGENETIC LEUKEMIC BLOOD STUDIES

Abbreviation:

FGFR1

Alternate names:

FISH
Fluorescence In Situ Hybridization
FGFR1
FGFR1 rearrangement
Trisomy 8
+8

Useful for:

Diagnose and classify specific eosinophilic myeloid neoplasms. FGFR1 gene rearrangements are likely resistant to current chemotherapies

This test can be useful to detect +8 in myeloid disorders.

This test can be ordered individually or as part of an Eosinophilia FISH Panel or Myelodysplastic Syndrome FISH panel. See the individual panel test for more details.

Specimen type:

Bone Marrow aspirate

Collection container:

Bone marrow aspirate:

Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube

- or -

Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep ), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times, to prevent clotting

Volume:

5 mL

Minimum volume:

3 mL

Collection instructions:

Transfer aspirate from syringe to transport container.

Processing instructions:

Submit entire specimen unspun.

Transport container:

Sterile vial/tube

Dk green Sodium heparin (Na hep ), no gel

Alternate specimen type:

Bone Marrow core
Sodium heparinized whole blood
Touch Prep slides

Alternate collection container:

Bone Marrow Core:

Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline

Whole blood:

Dk green Sodium heparin (Na hep ), no gel

Alternate specimen volume:

Bone Marrow core: 10 mm
Whole blood: 5 mL

Alternate collection instructions:

Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.

Alternate processing instructions:

Submit entire specimen unspun

Alternate transport container:

Sterile tube/cup

Dk green Sodium heparin (Na hep l ), no gel

Required forms/information:

AHL Cytogenetics Oncology Requisition

Transport and stability:

Ambient

Specimen retention time:

Specimens retained until completion of all testing

Reason for rejection:

Improper label (unlabeled or mislabeled)
Wrong container (anticoagulant or solution)
Delay in transport
Improper storage
Leaking container
Slides broken beyond repair

Performing lab:

AHL - Cytogenetics: X

Days set up:

Mo - Fr

TAT:

14 business days

Method:

Fluorescence in situ hybridization (FISH)

Reference ranges:

Normal or Abnormal with interpretation

CPT codes:

88271 x 2
88275
88291

Subject to medical necessity (Y/N):

Yes

LCD/NCD:

Medical necessity

Date created:

03/16/2021

Revised date:

09/13/2022

Review date:

04/06/2021