Anti-mitochondrial antibody

Alphabetical Test listing

Anti-mitochondrial antibody-652

  
Anti-mitochondrial antibody
  
652
  
86255.1
  
AMA
  
M2 antibodies
  
Serum
  
  
1.0 mL
  
0.3 mL
  

Spin

  

Gold serum separator (SST) tube

  
  
  1. Spin
  2. Transfer serum to a False bottom plasma/serum transport vial/tube (AHL)

 

  
  

Refrigerated (preferred) - 7 days

Frozen (OK)

  
  • Improper labels (unlabeled or mislabeled)
  • Hemolysis (some procedures)
  • Improper anticoagulant or ratio
  • Delay in transport
  • Improper storage temperature affecting results
  • Improper container
  • Leaking container resulting in compromised specimen
  • Quantity not sufficient (QNS)
  
AHL - Immunology: I
  
1 - 2 times/week
  
1 - 8 days
  

Indirect Fluorescent Antibody (IFA)

  

Negative (<1:20)

  

Anti-mitochondrial antibodies are present in 85 to 95 %t of cases of primary biliary cirrhosis. The presence of high titers of AMA is helpful in distinguishing biliary cirrhosis from liver problems due to obstruction outside of the liver, viral hepatitis, and alcoholic cirrhosis. Low titers may be detected in other liver disorders including chronic active hepatitis and cryptogenic cirrhosis.

Reflexes to titer if positive.

Screening is perfomed at 1:20 dilution. Titers performed: 1:40, 80, 160, 320 and 640

  
86255
  
11/30/2001
  
09/07/2018
  
02/17/2020