IgG4 by IHC

Alphabetical Test listing

IgG4 by IHC-12376 - Technical only, 12379 - Technical & interpretation

IgG4 by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • Elevated serum IgG4 levels may be associated with localized or systemic allergic and autoimmune manifestations, such as inflammatory pseudotumor in liver, breast, and lung, sclerosing pancreatitis, and pemphigus vulgaris
  • In these disease states, increased numbers of IgG4-positive plasma cells are present in the tissue



Submit a formalin-fixed, paraffin-embedded tissue


Formalin-fixed, paraffin-embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • Immunoglobulin function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system.
  • IgG represents one of the immunoglobulin heavy chain types
  • IgG4 is the least abundant of IgG subclasses, normally comprising 6% of total IgG

 Staining pattern

  • Cytoplasmic

88342 - 1st stain
88341 - each additional stain