IgG4 by IHC

Alphabetical Test listing

IgG4 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
IgG4 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Immunoglobulin
  
  • All IHC stains will include a positive control tissue
  
  • Elevated serum IgG4 levels may be associated with localized or systemic allergic and autoimmune manifestations, such as inflammatory pseudotumor in liver, breast, and lung, sclerosing pancreatitis, and pemphigus vulgaris
  • In these disease states, increased numbers of IgG4-positive plasma cells are present in the tissue

 

  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Immunoglobulin function as the surface receptors for antigens for B lymphocytes and as the secretory products of plasma cells forming the humoral arm of the immune system.
  • IgG represents one of the immunoglobulin heavy chain types
  • IgG4 is the least abundant of IgG subclasses, normally comprising 6% of total IgG

 Staining pattern

  • Cytoplasmic

  
88342 - 1st stain
88341 - each additional stain
  
10/30/2017
  
10/19/2018
  
10/02/2020