Synuclein by IHC

Alphabetical Test listing

Synuclein by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Synuclein by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
IHC
  
  • All IHC stains will include a positive control tissue
  
  • Synuclein is used to identify cytoplasmic inclusions in a number of neurodegenerative disorders collectively termed Synucleinopathies
  • The most frequent of the Synucleinopathies is Parkinson's disease; synuclein-positive Lewy bodies are usually easily found within the pigmented neurons of the substantia nigra
  • The immunohistochemical stain is most useful in other Synucleinopathies such as Dementia with Lewy Bodies (DLB) or Multiple System Atrophy (MSA), where inclusions may be found in cortical neurons (DLB) or oligodendroglia (MSA)
  • Lewy body variants of Alzheimer's disease (LBV) have also been characterized, and a small percentage of cognitively normal elderly will have occasional Lewy bodies
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Alpha-synuclein is a major component of Lewy bodies in Parkinson's disease, along with ubiquitin and associated enzymes

 Staining pattern

  • Cytoplasmic

  
88342 - 1st stain
88341 - each additional stain
  
09/13/2017
  
10/17/2018
  
10/02/2020