MUM1 by IHC

Alphabetical Test listing

MUM1 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
MUM1 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Multiple myeloma oncogene-1
  
  • All IHC stains will include a positive control tissue
  
  • MUM1 is useful in the subclassification of lymphoid malignancies
  • MUM1 expression has been identified in multiple myelomas, lymphoplasmacytic lymphomas, diffuse large B-cell lymphomas, and activated T cells<
  • MUM1 can also be used to identify Reed-Sternberg cells in Hodgkin's lymphoma
  • MUM1 is also present in benign and neoplastic melanocytic proliferations (92% of melanomas are MUM1 positive)
  • The presence of MUM1 staining in diffuse large B-cell lymphomas has been associated with a worse prognosis
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Recognizes the MUM1/IRF4 protein, which is expressed in late plasma-cell-directed stages of B-cell differentiation
  • MUM1 is useful in identifying transition from BCL6 positivity to CD138 expression
  • It is also expressed in activated T cells and in related hematologic neoplasms

Staining pattern

  • Nuclear staining, often with weak to moderate cytoplasmic staining

References:

  1. Colomo L et al: Diffuse large B-cell lymphomas with plasma-blastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol. 2004 Jun;28(6): 736-47.
  2. Sundram U et al: Expression of the B-cell proliferation marker MUM1 by melanocytic lesions and comparison with S100, gp100 (HMB45), and MelanA. Mod Pathol. 2003 Aug;16(8):802-10.
  3. Camacho FI et al: Nodal marginal zone lymphoma: a heterogeneous tumor: a comprehensive analysis of a series of 27 cases. Am J Surg Pathol. 2003 Jun;27(6):762-71.
  4. Natkunam Y et al: Analysis of MUM1/IRF4 protein expression using tissue micro-arrays and immunohistochemistry. Mod Pathol. 2001 Jul;14(7):686-94.
  5. Chang CC et al: Immunohistochemical expression patterns of germinal center and activation B-cell markers correlate with prognosis in diffuse large B-cell lymphoma. Am J Surg Pathol. 2004 Apr;28(4):464-70.
  6. Hans CP et al: Confirmation of the molecular classification of diffuse large B-cell lymphoma by immunohistochemistry using a tissue micro-array. Blood. 2004 Jan 1;103(1):275-82. Epub 2003 Sep 22.
  
88342 - 1st stain
88341 - each additional stain
  
07/18/2017
  
10/19/2018
  
10/02/2020