Progesterone receptor by IHC

Alphabetical Test listing

Progesterone receptor by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Progesterone receptor by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12379
LAB12379
  
PR
  
  • All IHC stains will include a positive control tissue
  
  • PR is used to determine if a tumor expresses estrogen receptor (i.e. for classification purposes)
  • PR positivity is used to determine if a patient would be a candidate for anti-estrogen therapy
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • PR is a nuclear protein that binds progesterone hormone
  • PR expression is seen in a variety of tumors from breast or gynecologic origin
  • PR expression can also be seen in tumors of lung, stomach, thyroid, and very rarely colorectal origin (PR is less specific than ER)

  Staining

  • Nuclear staining

References

  1. Aziz DC: Quantitation of estrogen and progesterone receptors by immunocytochemical and image analyses. Am J Clin Pathol 1992; 98:105-111.
  2. Wilbur DC et al: Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: A comparison of immunohistochemistry with the dextran-coated charcoal assay. Mod Pathol, 5(1), 1992.
  3. Esteban JM et al: Improvement of the quantification of estrogen and progesterone receptors in paraffin-embedded tumors by image analysis. Am J Clin Pathol, 1993; 99:32-38.
  4. Taylor CR: Paraffin section immunocytochemistry for estrogen receptor; the time has come. Cancer 77(12), 1996.
  
88342 - 1st stain
88341 - each additional stain
  
08/07/2017
  
10/19/2018
  
10/02/2020