Progesterone receptor by IHC

Alphabetical Test listing

Progesterone receptor by IHC-12376 - Technical only, 12379 - Technical & interpretation

Progesterone receptor by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • PR is used to determine if a tumor expresses estrogen receptor (i.e. for classification purposes)
  • PR positivity is used to determine if a patient would be a candidate for anti-estrogen therapy

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • PR is a nuclear protein that binds progesterone hormone
  • PR expression is seen in a variety of tumors from breast or gynecologic origin
  • PR expression can also be seen in tumors of lung, stomach, thyroid, and very rarely colorectal origin (PR is less specific than ER)


  • Nuclear staining


  1. Aziz DC: Quantitation of estrogen and progesterone receptors by immunocytochemical and image analyses. Am J Clin Pathol 1992; 98:105-111.
  2. Wilbur DC et al: Estrogen and progesterone receptor detection in archival formalin-fixed, paraffin-embedded tissue from breast carcinoma: A comparison of immunohistochemistry with the dextran-coated charcoal assay. Mod Pathol, 5(1), 1992.
  3. Esteban JM et al: Improvement of the quantification of estrogen and progesterone receptors in paraffin-embedded tumors by image analysis. Am J Clin Pathol, 1993; 99:32-38.
  4. Taylor CR: Paraffin section immunocytochemistry for estrogen receptor; the time has come. Cancer 77(12), 1996.
88342 - 1st stain
88341 - each additional stain