Epilepsy autoimmune evaluation, serum

Alphabetical Test listing

Epilepsy autoimmune evaluation, serum-12692

  
Epilepsy autoimmune evaluation, serum
  
12692
  
LAB12692
  
EPS2
  
ACh Receptor (Muscle) Binding Ab
AChR Ganglionic Ab
AMPA-R Ab CBA
Amphiphysin Ab
Paraneoplastic
  
  • AMPA-R Ab CBA, S
  • Amphiphysin Ab, S
  • Anti-Glial Nuclear Ab, Type 1
  • Anti-Neuronal Nuclear Ab, Type 1
  • Anti-Neuronal Nuclear Ab, Type 2
  • Anti-Neuronal Nuclear Ab, Type 3
  • CASPR2-IgG CBA, S
  • CRMP-5-IgG, S
  • DPPX Ab IFA, S
  • Epilepsy, Interpretation, S
  • GABA-B-R Ab CBA, S
  • GAD65 Ab Assay, S
  • GFAP IFA, S
  • LGI1-IgG CBA, S
  • mGluR1 Ab IFA, S
  • NMDA-R Ab CBA, S
  • Purkinje Cell Cytoplasmic Ab Type 2
  • Purkinje Cell Cytoplasmic Ab Type Tr
  
Investigating new onset cryptogenic epilepsy with incomplete seizure control and duration of less than 2 years

Investigating new onset cryptogenic epilepsy plus 1 or more of the following accompaniments:
-Psychiatric accompaniments (psychosis, hallucinations)
-Movement disorder (myoclonus, tremor, dyskinesias)
-Headache
-Cognitive impairment/encephalopathy
-Autoimmune stigmata (personal history or family history or signs of diabetes mellitus, thyroid disorder, vitiligo, premature graying of hair, myasthenia gravis, rheumatoid arthritis, systemic lupus erythematosus, idiopathic adrenocortical insufficiency), or multiple sclerosis
-History of cancer
       -Smoking history (20+ pack years) or other cancer risk factors
-Investigating seizures occurring within the context of a subacute multifocal neurological disorder without obvious cause, especially in a patient with past or family history of cancer
-A rising autoantibody titer in a previously seropositive patient suggests cancer recurrence
  
  • For optimal antibody detection, specimen collection is recommended prior to initiation of immunosuppressant medication
  • This test should not be requested in patients who have recently received radioisotopes, therapeutically or diagnostically, becuase of potential assay interference. The specific waiting period before specimen collection will depend on the isotope administered, the dose given and the clearance rate in the individual patient. Specimens will be screened for radioactivity prior to analysis. Radioactive specimens received at MCL will be held 1 week and assayed at that time if sufficiently decayed, or canceled if radioactivity remains.
  • Patient should have no general anesthetic or muscle-relaxant drugs in the previous 24 hours
  
Serum
  
  
4.0 mL
  
2.5 mL
  

Spin and separate

  
  
  

Spin and separate

  

Refrigerated (preferred) - 28 days

Frozen - 28 days

Ambient - 72 hours

  
Mayo Clinic Laboratories (EPS2): R
  
Daily
  
10 - 13 days
  

Indirect Immunofluorescence Assay (IFA), Live Cell Assay (LCA), Cell binding assay (CBA), Western blot (WB), and Immunoprecipitin Assay (IPA)

  
86255 x 16
86341

Additional CPT codes (if appropriate):
83519 x 2
84182 x 7
86255 x 4
86256 x 6
  
11/18/2014
  
07/16/2021
  
05/11/2021