Immediatley following collection, mix sample thoroughly by gentle inverting 8 - 10 times, to prevent clotting
Transfer plasma to a Transfer vial/tube with cap - 12mL (LabCorp), labelled as the appropriate plasma type, within 45 minutes of sample collection
Ambient (preferred) - 14 days
Refrigerated - 14 days
Frozen - 14 days
Freeze/thaw cycles - stable x3
The use of gel-barrier tubes is not recommended due to slow absorption of the drug by the gel. Depending on the specimen volume and storage time, the decrease in drug level due to absorption may be clinically significant.
LabCorp Burlington (706887): R-NX
Mo - Fr
Liquid chromatography/tandem mass spectrometry (LC/MS-MS)
Therapeutic: 1.0-10.0 ng/mL
Its dose in milligrams equivalent to 100 mg of chlorpromazine is 0.6-1.2 mg. A statistical evaluation1 of clinical studies found the near maximal effective dose of oral fluphenazine to be <6.9 mg/day. For the decanoate, the near-maximal effective dose was 25 mg/two weeks. As a high potency antipsychotic, it may have a high potential for causing extrapyramidal side effects. This would be in addition to the usual adverse effects of antipsychotic drugs (neurologic, anticholinergic, hypotension). Elderly patients should be observed for these occurrences. The half-life of fluphenazine is formulation-dependent. (The decanoate is 5 to 12 days; the hydrochloride 12 to 60 hours.) Fluphenazine is also used to alleviate pain and in childhood development disorders.