MOC-31 by IHC

Alphabetical Test listing

MOC-31 by IHC-12376 - Technical only, 12379 - Technical & interpretation

MOC-31 by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • The primary use for this antibody is in distinguishing between epithelial versus mesothelial proliferations. It is one of the best markers currently available in recognizing adenocarcinoma
  • This antibody should be used in a panel (see mesothelioma vs. adenocarcinoma panel)

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • MOC-31 is an antibody directed against a small cell carcinoma cell line
  • It reacts with an epithelial antigen present on most normal and malignant epithelia
  • Reactive mesothelial cells and malignant mesotheliomas show rare expression with this antibody

Staining pattern

  • Membrane based staining


  1. Sosolik RC, et al. Anti-MOC-31: a potential addition to the pulmonary adenocarcinoma versus mesothelioma immunohistochemistry panel. Mod Pathol 1997; 10:716-719.
  2. Ordonez NG. The immunohistochemical diagnosis of epithelial mesothelioma. Hum Pathol 1999; 30:313-23.
  3. Ruitenbeek T, et al. Immunocytology of body cavity fluids. MOC031, a monoclonal antibody discriminating between mesothelial and epithelial cells. Arch Pathol Lab Med 1994; 118:265.
88342 - 1st stain
88341 - each additional stain