Bielschowsky Silver stain

Alphabetical Test listing

Bielschowsky Silver stain-12376 - Technical only, 12379 - Technical & interpretation

Bielschowsky Silver stain
12376 - Technical only, 12379 - Technical & interpretation
Nerve fibers
Neurofibrillary tangles
Senile plaques
Special stain

All special stains will include a positive control tissue


This procedure is used for the demonstration of nerve fibers and the presence of neurofibrillary tangles and senile plaques in Alzheimer disease. 

As aging occurs, most individuals develop alteration of neurofibrils in at least some neurons; the neurofibrils may become clumped or twisted.  In Alzheimer disease, tremendous numbers of the neurofibrillary tangles develop.


Formalin vial/container


Prepare a formalin-fixed, paraffin-embedded (FFPE) tissue block


FFPE tissue block


Prepare two (2) 8 micron thick section unstained positively charged slides from an FFPE tissue block


Histopathology Processing & Special Stains requisition



Protect paraffin block and/or slides from excessive heat

  • Insufficient tissue in block
  • Mislabeled/Unlabeled block or slides
  • Broken slides
AHL - Histology: A
Mo - Fr
24 - 48 hours

Histochemical staining and microscopic evaluation


An interpretive pathology report will be provided for Technical with Interpretation cases.