Cytochrome P450 2D6 genotyping

Alphabetical Test listing

Cytochrome P450 2D6 genotyping-13652

Cytochrome P450 2D6 genotyping
DME Genotyping

This testing can assist with customizing drug therapy by providing metabolic activity information that may explain patient drug responses relevant to CYP2D6 genetic variability. The cytochrome P450 (CYP450) enzymes metabolize many drugs. Individual genetic differences of cytochrome P450 activity can result in the total absence of metabolism to ultrafast metabolism of certain drugs.

EDTA whole blood
5.0 mL
3.0 mL

Lavender (EDTA), 4 mL

ACD whole blood

Yellow ACD (A or B)



Yellow ACD (A or B)


 Molecular Medicare billing request

  • Complete and submit the form to notify us of the need for Allina Health Laboratory to bill insurance for Molecular testing performed
  • All information requested is required in order for your request to be completed

Ambient (preferred) - 7 days

Refrigerated - 7 days

Frozen - 2 years

  • Hemolysis
  • Quantity not sufficient for analysis (QNS) 
  • Improper container


Esoterix Coagulation (301553) via LabCorp (511230): R-LC
Twice per week
6 - 10 days

DNA analysis of the Cytochrome P450 2D6 gene (OMIM 124030) is performed using primer extension chemistry. Multiplex PCR amplifies DNA fragments containing the variants below. Primer extension then generates a biotin-labeled product to permit flow-sorted detection of both normal and variant sequences. Molecular-based testing is highly accurate, but as in any laboratory test, rare diagnostic errors may occur. .

Alleles detected: *1, *2, *3, *4, *5, *6, *7, *8, *9, *10, *11, *15, *17, *29, *35, *41, and gene duplications.

Variant *5 is a gene deletion. Copy number of duplicated alleles is not determined. Duplications are often functional (whole gene) but may be nonfunctional (partial gene). It is not always possible to determine which allele is duplicated. 

*1 represents detection of the normal sequence for the variants tested.


An interpretive report will be provided

This test may require preauthorization from the insurance provider. Check the payer guidelines and, if needed, obtain the pre-authorization prior to sample collection.
Result 40425-1