Pepsinogen I is produced primarily in the Oxyntic gland mucosa of the stomach. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen I has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Pepsinogen I is cleared by the kidney and secreted into the urine. Patients with pernicious anemia and gastrectomized patients have low to non-detectable levels of Pepsinogen I. Pepsinogen I levels are slightly elevated in gastric ulcer, higher in gastroduodenal ulcer and significantly elevated in duodenal ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels. Pepsinogen I has been shown to correlate with presence of genetic duodenal ulcer, and has been used as a subclinical marker of increased risk for stomach cancer.
Frozen (strict) - 365 days
Refrigerated - NO
Ambient - NO
Direct Radioimmunoassay (Direct RIA)
An interpretive report will be provided