Pepsinogen I

Alphabetical Test listing

Pepsinogen I-994

Pepsinogen I

Pepsinogen I is produced primarily in the Oxyntic gland mucosa of the stomach. It is secreted mainly into the gastric lumen and into circulation. Pepsinogen I has little or no biological activity but in acid is converted to the active enzyme Pepsin which exhibits proteolytic actions. Pepsinogen I is cleared by the kidney and secreted into the urine. Patients with pernicious anemia and gastrectomized patients have low to non-detectable levels of Pepsinogen I. Pepsinogen I levels are slightly elevated in gastric ulcer, higher in gastroduodenal ulcer and significantly elevated in duodenal ulcer. Patients with Zollinger-Ellison's syndrome exhibit greatly elevated levels. Pepsinogen I has been shown to correlate with presence of genetic duodenal ulcer, and has been used as a subclinical marker of increased risk for stomach cancer.

  • Patient should be fasting 10-12 hours prior to collection of specimen
  • Antacids or other medications affecting stomach acidity or gastrointestinal motility should be discontinued, if possible, for at least 48 hours prior to collection.
3.0 mL
1.0 mL
  1. Spin to separate serum from the cells within 45 minutes of specimen collection
  2. Freeze immediately
EDTA plasma
  1. Spin to separate plasma from the cells within 45 minutes of specimen collection
  2. Freeze immediately

Frozen (strict) - 365 days

Refrigerated - NO

Ambient - NO

Interscience Institute ( ) via LabCorp (276045): R-NX
Varies, 1 x / week
7 days

Direct Radioimmunoassay (Direct RIA)


An interpretive report will be provided

Result 2736-7