MyoD1 by IHC

Alphabetical Test listing

MyoD1 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
MyoD1 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Rhabdomyosarcoma marker
  
  • All IHC stains will include a positive control tissue
  
  • MyoD1 is present in the majority of rhabdomyosarcomas (RMS), and is a superior marker for the less differentiated RMS
  • Stronger staining has been reported in alveolar vs. embryonal RMS
  • Normal mature skeletal muscle does not express MyoD1
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • MyoD1 is a myogenic nuclear regulatory protein that is normally expressed during embryogenesis, early in skeletal muscle differentiation
  • Nuclear expression of MyoD1 is restricted to myoblasts of developing skeletal muscle tissue

Staining pattern

  • Nuclear
  • Cytoplasmic staining is non-specific, and should be ignored

References:

  1. Morotti RA et al: Am J Surg Pathol 2006;30:962-968. Sebire NJ et al: J clinPathol 2003;56:412-416.
  
88342 - 1st stain
88341 - each additional stain
  
10/27/2017
  
10/19/2018
  
10/02/2020