Calcitonin by IHC

Alphabetical Test listing

Calcitonin by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
Calcitonin by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
  • All IHC stains will include a positive control tissue
  

The primary use for this antibody is in identifying the calcitonin production in thyroid (c-cell hyperplasia and medullary carcinoma) as well by other tumors

  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • Calcitonin secretion occurs in normal and neoplastic thyroid, and results in hypocalcemic actions on bone and kidney
  • Calcitonin secretion is usually associated with medullary carcinoma of the thyroid, as well as in C-cell hyperplasia
  • The identification of calcitonin production in c-cell hyperplasia is useful in recognizing familial forms of this disease
  • Calcitonin secretion has also been demonstrated in thymic carcinoids, as well as in breast and lung cancers (such as small cell carcinomas)

 Staining patterns

  • Cytoplasmic based granular activity

References:

  1. Melvin KEWQ et al, N Eng J Med 285:1115-1120, 1970.
  2. DeLellis RA et al, Am J Pathol 72:119-128, 1973
  
88342 - 1st stain
88341 - each additional stain
  
05/15/2017
  
10/17/2018
  
10/02/2020