BCL-6 by IHC

Alphabetical Test listing

BCL-6 by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
BCL-6 by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  

All IHC stains will include a positive control tissue

  
  • BCL6 staining is seen in follicular lymphomas, approximately 30% of diffuse large B cell lymphomas, Burkitt lymphomas, and nodular lymphocyte-predominant Hodgkin’s disease
  • In normal tissues, BCL6 stains follicular center B-cells of the germinal centers, and some T-cells in the germinal centers; the staining pattern is reciprocal to that of Bcl-2
  • BCL6 staining is not seen in B-CLL, hairy cell leukemia, and mantle and marginal-zone lymphomas
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

Tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • BCL6 is a protein expressed by germinal center B-lymphocytes and serves as a transcriptional regulatory protein
  • BCL6 expression is seen in a variety of B cell lymphomas

 Staining patterns

  • Nuclear staining

References

  1. Falini B, et al: Bcl-6 protein expression in normal and neoplastic lymphoid tissues. Ann Oncol 8, Suppl, 2:101-104, 1997.
  2. Flenghi L, et al: A specific monoclonal antibody detects expression of the BCL-6 protein in germinal center B cells. Am J Pathol 147:405-411, 1995.
  3. Falini B, et al: Distinctive expression pattern of the BCL-6 protein in nodular lymphocyte predominance Hodgkin’s disease. Blood 87:465-71, 1996.

 

  
88342 - 1st stain
88341 - each additional stain
  
05/10/2017
  
10/17/2018
  
10/02/2020