Lipoprotein(a)

Alphabetical Test listing

Lipoprotein(a)-14447

  
Lipoprotein(a)
  
14447
  
LAB14447
  
LPA
  
Lpa
  

Quantitation of Lp(a)

  

Lp(a) determination is intended for use in conjunction with clinical evaluation, patient risk assessment, and other lipid tests to evaluate disorders of lipid metabolism and to assess coronary heart disease in specific populations.

  

Intake of alcohol, aspirin, niacin, and estrogen supplements have the potential of causing a misrepresentation of true Lp(a) concentrations.

  
Serum
  
  
0.5 mL
  
0.2 mL
  

Spin to separate the serum from the cells within 2 hours of specimen collection.

  

Gold serum separator (SST) tube

  
EDTA plasma
Heparin plasma
Sodium citrate (Na cit) plasma
  
  
  1. Spin
  2. Transfer serum or plasma to a Transfer vial/tube with cap - 12mL (LabCorp) within 2 hours of specimen collection
  
  

Refrigerated (preferred) – 14 days

Frozen - >14 days

Ambient - NO

  
  • Gross hemolysis
  • Gross lipemia
  • Icteric specimen
  
LabCorp (120188): R-LC
  
Mo - Sa
  
2 - 4 days
  

Immunoturbidimetric

  

<75.0 nmol/L

Values ≥75.0 nmol/L may indicate independent risk factor for CHD.

  

Measurement of lipoprotein(a) is now recommended in several patient subgroups for whom excess lipoprotein(a) may have important clinical consequences: (1) patients with premature atherosclerosis, (2) patients with a strong family history of premature coronary heart disease (CHD), (3) patients with elevated LDL-C and greater than or equal to two risk factors, (4) patients who have had coronary angioplasty in whom lipoprotein(a) excess may increase the risk of restenosis, and (5) patients who have undergone coronary bypass graft surgery in whom Lp(a) excess may be associated with graft stenosis.

Lipoprotein(a) has been called a powerful predictor of premature atherosclerotic vascular disease. As an independent risk factor for premature coronary artery disease, excess Lp(a) concentrations are associated with an increased risk of cardiac death in patients with acute coronary syndromes and with restenosis after angioplasty (PTCA) and coronary bypass procedures. In general, concentrations greater than or equal to 75 nmol/L of Lp(a) in serum are associated with a two- to sixfold increase in risk, depending on the presence of other risk factors.

  
83695
  
03/01/2021
  
03/01/2021