Neu-N by IHC

Alphabetical Test listing

Neu-N by IHC-12376 - Technical only, 12379 - Technical & Interpretation

  
Neu-N by IHC
  
12376 - Technical only, 12379 - Technical & Interpretation
  
LAB12376
LAB12379
  
Anti-neuronal nuclei
  
  • All IHC stains will include a positive control tissue
  
  • NeuN is used to identify neurons within brain parenchyma when infiltrating glial neoplasms obscure normal brain architecture, hence it can be useful to confirm brain infiltration
  • NeuN may also be useful in confirming neuronal phenotypes in biphenotypic CNS tumors like gangliogliomas
  • Unlike other neuronal markers (synaptophysin, neurofilament), NeuN does not stain the background neuropil
  • It may also be used to help assess cortical neuronal cytoarchitecture in suspected migrational disorders
  
Tissue
  

Submit a formalin-fixed, paraffin embedded tissue block

  

Formalin-fixed, paraffin embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • NeuN is a neuron-specific nuclear protein, which is present within most neuronal cell types within the central nervous system, spinal cord, and peripheral nervous system including ganglion cells
  • NeuN does not stain Purkinje cells of the cerebellum

 Staining pattern

  • Nuclear

References

  1. Mullen RJ, Buck CR, Smith AM. NeuN, a neuronal specific nuclear protein in vertebrates. Development 1992;116:201-11
  
88342 - 1st stain
88341 - each additional stain
  
07/18/2017
  
10/19/2018
  
10/02/2020