MPL mutation analysis

Alphabetical Test listing

MPL mutation analysis-13552

  
MPL mutation analysis
  
13552
  
LAB13552
  
MPL
  
Myeloproliferative leukemia oncogene homology
  

MPL W515 mutations are present in patients with primary myelofibrosis (PMF) and essential thrombocythemia (ET) at a frequency of approximately 5% and 1% respectively. The S505 mutation is detected in patients with hereditary thrombocythemia.

  
EDTA whole blood
  
  
5.0 mL
  
3.0 mL
  

Lavender (EDTA) tube

 

  
Sodium heparin (Na hep) whole blood
Bone marrow cell pellet
  
  
Sodium heparin whole blood - 5mL (minimum 3mL)
Bone marrow cell pellet - 2.0 mL (minimum 1.0 mL)
  

Dk green Sodium heparin (Na hep), no gel

Sterile vial/container

  

Ambient

If specimen is to be stored prior to shipment, store at 2 - 8°C.

  

Specimen does not meet collection criteria; frozen whole blood, marrow, or cell pellet; leaking tube; clotted blood or marrow; grossly hemolyzed specimen or otherwise visibly degraded; contamination by another specimen; specimens containing suspicious foreign material.

  
LabCorp RTP (489150): R-LC
  
Mo - Fr
  
7 - 12 days
  

Polymerase chain reaction (PCR) and DNA sequencing

  

An interpretive report will be provided

  

MPL (myeloproliferative leukemia virus oncogene homology) belongs to the hematopoietin superfamily and enables its ligand thrombopoietin to facilitate both global hematopoiesis and megakaryocyte growth and differentiation.

  
81338
  
Yes
  
  
Result 62947-7
  
04/10/2019
  
01/07/2021
  
03/16/2021