MPL mutation analysis

Alphabetical Test listing

MPL mutation analysis-13552

MPL mutation analysis
Myeloproliferative leukemia oncogene homology

MPL W515 mutations are present in patients with primary myelofibrosis (PMF) and essential thrombocythemia (ET) at a frequency of approximately 5% and 1% respectively. The S505 mutation is detected in patients with hereditary thrombocythemia.

EDTA whole blood
5.0 mL
3.0 mL

Lavender (EDTA) tube


Sodium heparin (Na hep) whole blood
Bone marrow cell pellet
Sodium heparin whole blood - 5mL (minimum 3mL)
Bone marrow cell pellet - 2.0 mL (minimum 1.0 mL)

Dk green Sodium heparin (Na hep), no gel

Sterile vial/container



If specimen is to be stored prior to shipment, store at 2 - 8°C.


Specimen does not meet collection criteria; frozen whole blood, marrow, or cell pellet; leaking tube; clotted blood or marrow; grossly hemolyzed specimen or otherwise visibly degraded; contamination by another specimen; specimens containing suspicious foreign material.

LabCorp RTP (489150): R-LC
Mo - Fr
7 - 12 days

Polymerase chain reaction (PCR) and DNA sequencing


An interpretive report will be provided


MPL (myeloproliferative leukemia virus oncogene homology) belongs to the hematopoietin superfamily and enables its ligand thrombopoietin to facilitate both global hematopoiesis and megakaryocyte growth and differentiation.

Result 62947-7