IgD by IHC

Alphabetical Test listing

IgD by IHC-12376 - Technical only, 12379 - Technical & interpretation

  
IgD by IHC
  
12376 - Technical only, 12379 - Technical & interpretation
  
LAB12376
LAB12379
  
Anti-human IgD
  
  • All IHC stains will include a positive control tissue
  
  • In paraffin tissue, the antibody labels plasma cells with IgD
  • IgD labels B cell lymphocytes in primary follicles
  • In secondary follicles, the staining is in the mantle zone with coarse meshwork of IgD in the germinal centers (this represents immune complexes present on the surface of dendritic reticulum cells
  
Tissue
  

Submit a formalin-fixed, paraffin-embedded tissue

  

Formalin-fixed, paraffin-embedded (FFPE) tissue block

  

FFPE tissue section mounted on a charged, unstained slide

  

Ambient (preferred)

  
  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
  
AHL - Immunohistochemistry
  
Mo - Fr
  
1 - 2 days
  

Immunohistochemical staining and microscopic examination

  

If requested, an interpretive report will be provided

  

Specifications

  • The antibody reacts with the heavy chain (delta chain) of human IgD
  • This antibody labels plasma cells, and various lymphocytes (the later depends on the methodology - i.e. frozen vs. paraffin)

 
Staining pattern

  • Cytoplasmic (plasma cells) and cell surface membrane (lymphocytes)

References

  1. Mason DY et al: Blood 1987; 69:836-40.
  2. Falini B et al: Histopathology 1986; 10:671-87.
  3. Erber WN et al: Lancet 1986; 1:761-5.
  
88342 - 1st stain
88341 - each additional stain
  
10/30/2017
  
10/19/2018
  
10/02/2020