Neuron-specific enolase by IHC

Alphabetical Test listing

Neuron-specific enolase by IHC-12376 - Technical only, 12379 - Technical & Interpretation

Neuron-specific enolase by IHC
12376 - Technical only, 12379 - Technical & Interpretation
  • All IHC stains will include a positive control tissue
  • May be useful in a panel for neuroendocrine tumors
  • Other more specific neuroendocrine markers include chromogranin, Synaptophysin, and Leu-7
  • Infrequent positive staining in many non-neuroendocrine tumors has been identified with NSE due to cross-reactivity

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • NSE is an isoenzyme of the glycolytic enzyme enolase that is expressed primarily in neurons and neuroendocrine tissues
  • NSE is also expressed in platelets, T-lymphocytes, megakaryocytes, striated and smooth muscle cells

Staining pattern

  • Diffuse cytoplasmic

88342 - 1st stain
88341 - each additional stain