SOX10 by IHC

Alphabetical Test listing

SOX10 by IHC-12376 - Technical only, 12379 - Technical & interpretation

SOX10 by IHC
12376 - Technical only, 12379 - Technical & interpretation
  • All IHC stains will include a positive control tissue
  • SOX10has been reported to be highly sensitive (97-100%) for both primary and metastatic melanomas, and is expressed in all subtypes
  • SOX10 is more sensitive and specific for desmoplastic melanoma than S100; it can help distinguish melanoma from background scar tissue
  • In tumors, it labels melanoma and tumors of neural crest origin such as Schawwn cell tumors, and glial cells
  • This marker is also expressed in clear cell sarcomas and peripheral nerve sheath tumors and is absent in angiomyolipomas
  • SOX10is present in both luminal and positive tumors include acinic cell, adenoid cystic, epithelial-myoepithelial and myoepithelial, carcinomas and pleomorphic adenomas. In contrast, salivary duct, mucoepidermoid, oncocytic and squamous cell carcinomas are SOX10 negative, as are Warthin tumors
  • This marker has been reported in basal like breast cancers
  • Rare examples of squamous cell carcinomas of the head and neck and pulmonary small cell carcinomas have been reported to stain for this marker
  • Pathologists should consider if entrapped non-neoplastic Schwann cells or melanocytes are present before diagnosing a SOX10 positive tumor

Submit a formalin-fixed, paraffin embedded tissue block


Formalin-fixed, paraffin embedded (FFPE) tissue block


FFPE tissue section mounted on a charged, unstained slide


Ambient (preferred)

  • Unlabeled/mislabeled block
  • Insufficient tissue
  • Slides broken beyond repair
AHL - Immunohistochemistry
Mo - Fr
1 - 2 days

Immunohistochemical staining and microscopic examination


If requested, an interpretive report will be provided



  • SOX10 is a member of the SOX family of transcription factors involved in regulation of embryonic development and cell fate
  • It is expressed in cells of schwannian and melanocytic lineages, and thus is a marker for schwannian and melanocytic tumors of skin and soft tissue
  • It is also a useful marker for myoepithelial and basal cell neoplasms

 Staining pattern

  • Nuclear staining


  1. ZHU S et al: Review and Updates of Immunohistochemistry in Selected Salivary Gland and Head and Neck Tumors. Arch Pathol Lab Med. 2015;139:55-66).
  2. Miettinen M et al: SOX10-A marker for not only schwannian and melanocytic neoplasms but also myoepithelial cell tumors of soft tissue; a systematic analysis of 5134 tumors. Am J Surg Pathol 2015;00:000-000.
  3. Ordonez N. Value of SOX10 immunostaining in tumor diagnosis. Adv Anat Pathol. 2013;20:275-283.
  4. Ordonez N: Value of melanocytic-associated immunohistochemical markers in the diagnosis of malignant melanoma; a review and update. Hum Pathol 45; 191-205, 2014.
88342 - 1st stain
88341 - each additional stain