Anti-cN-1A Ab (NT5c1A) IBM (RDL)

Alphabetical Test listing

Anti-cN-1A Ab (NT5c1A) IBM (RDL)-994

Test name:

Test number:

994

Excellian order number:

LAB994

Abbreviation:

MSO

Alternate names:

Anti-IBM
IBM
Inclusion body myopathy
MUP44 AB
nt5c1a
sIBM
Sporadic IBM

Useful for:

Anti-cN-1A autoantibodies in idiopathic inflammatory myopathy (IIM) patients appear to be disease-specific for sporadic Inclusion Body Myositis (sIBM) and are rarely detected in other autoimmune conditions. Anti-cN-1A autoantibodies have a moderate sensitivity, but their high specificity for sIBM may be helpful in the diagnosis of this infrequent and difficult-to-diagnose myopathy. This assay can augment and accelerate the suspected diagnosis of sIBM using sera where muscle biopsy is delayed and/or unfeasible.

Specimen type:

Serum

Collection container:

Gold serum separator (SST) tube

Volume:

2.0 mL

Minimum volume:

0.5 mL

Collection instructions:

Immediatley following collection, mix sample by gently inverting 5 times

Processing instructions:

Allow sample to clot for a minimum of 30 minutes
Spin within one (1) hour of sample collection

Transport container:

Gold serum separator (SST) tube

Alternate collection container:

Red serum vial/tube - 5 mL

Alternate processing instructions:

Allow sample to clot
Spin to separate serum from cells and transfers serum to a Transfer vial/tube with cap - 12mL (LabCorp) labelled as "serum" within one (1) hour of sample collection

Alternate transport container:

Transfer vial/tube with cap - 12mL (LabCorp)

Transport and stability:

Refrigerated (preferred) - 14 days

Ambient - 7 days

Frozen - 60 days

Reason for rejection:

Grossly hemolyzed
Bacterial contamination
Lipemic specimen
Icteric specimen
Non-serum specimen types

Performing lab:

LabCorp (520061): R-NX

Days set up:

Once per week

TAT:

14 - 21 days

Method:

Enzyme-linked immunosorbent assay (ELISA)

Reference ranges:

Negative: <20

CPT codes:

83520

Date created:

08/18/2020

Review date:

08/18/2020