RUNX/RUNX1 or t(8;21) is a recurring abnormality in AML. According to current NCCN AML guidelines, a t(8;21) result is classified as a favorable cytogenetics risk factor.
This test can be ordered individually or as part of the AML FISH Panel. See the panel test for more details
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun.
Dk green Sodium heparin (Na hep), no gel
Bone marrow core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10, times to prevent clotting.
Submit entire specimen unspun
AHL Cytogenetics Oncology Request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation