RUNX/RUNX1 by FISH
RUNX/RUNX1 by FISH-4280H (blood) or 4280G (bone marrow)
LAB4280G - CYTOGENETIC BONE MARROW STUDIES
Acute Myeloid Leukemia
FISH
Fluorescence in situ hybridization
t(8;21)
Detecting RUNX/RUNX1 or t(8;21), a recurring abnormality in AML.
This test can be ordered individually or as part of the AML FISH Panel. See the panel test for more details
- Only one specimen tube is required to perform all ordered cytogenetics testing.
- The more testing requested, the closer to the optimal volume requirements is required.
Dk green Sodium heparin (Na hep), no gel
EDTA whole blood (a chromosome analysis study is not recommended for this specimen type)
Bone marrow
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Collect bone marrow in sterile syringe (non-heparinized) and transfer to a Dk green Sodium heparin (Na hep), no gel
Bone marrow:
Sterile vial/tube
Dk green Sodium heparin (Na hep), no gel
EDTA whole blood:
Lavender (EDTA), 4mL
- AHL Cytogenetics oncology request
Ambient
- Improper label (unlabeled or mislabeled)
- Wrong container (anticoagulant or solution)
- Improper blood/anticoagulant ratio
- Delay in transport
- Improper storage
- Leaking container
STAT: Available upon request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation
t(8;21) RUNX/RUNX1 rearrangements are classified as favorable cytogenetics prognostic indicators in AML.