Rearrangements of FGFR3/IGH are recurring abnormalities in plasma cell dyscrasia disorders including Plasma Cell Myeloma. According to current mSMART 3.0 myeloma guidelines, rearrangement of FGFR3/IGH is classified as a high-risk cytogenetics category.
This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel. See the individual panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun. Specimen will be CD138 enriched for plasma cell isolation.
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen.
AHL Cytogenetics Oncology Request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation