Rearrangements of FGFR3/IGH are recurring abnormalities in plasma cell dyscrasia disorders including Plasma Cell Myeloma. According to current mSMART 3.0 myeloma guidelines, rearrangement of FGFR3/IGH is classified as a high-risk cytogenetics category.
This test can be ordered individually or as part of a Plasma Cell Dyscrasia FISH Panel. See the individual panel test for more details.
Bone marrow aspirate:
Collect bone marrow aspirate in a sterile Sodium heparin (Na hep) syringe and transfer to a sterile vial/tube
- or -
Transfer aspirate from syringe to transport container.
Submit entire specimen unspun. Specimen will be CD138 enriched for plasma cell isolation.
Bone Marrow Core:
Submit in sterile tube/cup filled with sterile culture medium, sterile Hanks Balance Salt Solution (HBSS) or sterile saline
Dk green Sodium heparin (Na hep), no gel
Immediately following collection, mix sample thoroughly by gently inverting 8 - 10 times to prevent clotting.
Submit entire specimen.
AHL Cytogenetics Oncology Request
Fluorescence in situ hybridization (FISH)
Normal or Abnormal with interpretation